Polynucleotide treatments are being hailed as the secret to firm and hydrated skin, with an envious list of celebrity fans. But do they really work? Here’s the science behind them.
Polynucleotides are highly purified DNA molecules extracted from fish. These molecules play a critical role in skin rejuvenation by targeting fibroblasts, the cells responsible for producing collagen and maintaining the skin’s structural integrity i.e. the skin’s firm structure.
As we age, collagen declines, and we notice fine lines and wrinkles. Polynucleotides stimulate the fibroblasts to produce more collagen, leading to firmer, smoother skin without deep lines.
What are polynucleotide injectables?
Polynucleotide injectables are composed of long chains of nucleotides, which are the building blocks of DNA. These injectables are designed to promote skin regeneration, hydration, and healing by stimulating the skin’s natural repair processes. They are often used in mesotherapy and bio-revitalisation skin treatments, where small amounts are injected into the dermis.
How do polynucleotide injectables work?
Stimulate collagen and elastin production
Polynucleotides encourage the production of collagen and elastin, two key proteins that keep the skin firm, elastic, and youthful. This helps to reduce fine lines and wrinkles, leading to smoother skin.Improve skin hydration
The injectables attract and retain moisture, leading to increased hydration in the deeper layers of the skin. This results in plumper, more radiant skin.Enhance cell regeneration
Polynucleotides help accelerate the skin’s healing process, making them ideal for treating damaged skin, scars, or sun damage. They also improve skin texture and tone over time.Reduce inflammation
These injectables possess anti-inflammatory properties, making them effective for calming irritated or inflamed skin, which is useful in treating conditions like acne or post-inflammatory hyperpigmentation.
Benefits of polynucleotide injectables
They have become a popular choice in aesthetic medicine, especially for aesthetic treatments, anti-ageing treatments and skin rejuvenation. Their benefits include:
Anti-ageing: Reduces wrinkles, fine lines, and sagging skin.
Hydration: Deeply hydrates the skin, improving its texture and glow.
Rejuvenation: Stimulates regeneration for healthier, more youthful skin.
Scar treatment: Promotes healing of acne scars or surgical scars.
Skin elasticity: Enhances firmness and elasticity, particularly in the neck, face, and hands.
Treatment process
Consultation: We will assess your skin’s needs and create a treatment plan.
Injection: Small amounts of the polynucleotide solution are injected into targeted areas using very fine needles. The process is usually quick and may take 20-30 minutes, depending on the area being treated.
Recovery: There may be slight swelling, redness, or bruising post-treatment, but this typically subsides within a few days.
Cost – £275 to have the treatment with Katie and £375 to have the treatment with Jan. Course packages are also available.
Results and maintenance:
Initial effects: Most people notice improved skin texture and hydration within 1-2 weeks after the first treatment.
Long-term benefits: For more pronounced effects, 2-3 sessions spaced about 2-4 weeks apart may be recommended. Results typically last 6-12 months, after which maintenance sessions may be required.
Where can polynucleotides be used?
Around the eyes – Polynucleotides can be injected around the eye area to help improve the appearance of dark circles, wrinkles and crepey skin. It can be injected close to the eye and over the eyelids to help with skin laxity.
Midface and jawline – High-concentration polynucleotides can be used along the jawline and midface for contouring and skin tightening, as well as improving skin tone and elasticity. Further benefits include bio-stimulation, faster healing and tissue improvement (as a post-surgery treatment), protects against free radicals and cellular damage.
On the neck, decolletage and hands – Polynucleotides can used to combat signs of aging, wrinkles and crepey skin in these visible areas.
Head and facial hair – They can also be used to stimulate hair growth for the scalp, beard and moustache.
Polynucleotide injectables can be combined with other non-surgical treatments like microneedling, PRP (platelet-rich plasma), laser therapy or skin tightening devices (e.g., RF or ultrasound-based therapies) to enhance the overall results of neck rejuvenation.
Polynucleotide treatments can help improve skin hydration, firmness, and texture, but they are not a “miracle cure.” While celebrity endorsements can make these treatments sound magical, it’s essential to consult with an expert (such as Blemish Clinic) who can assess your skin and recommend an evidence-backed approach tailored to your skin health and your goals. They are often part of a broader skincare regimen rather than a standalone solution.
Polynucleotide treatments FAQs
What are Polynucleotides?
Polynucleotides are molecules derived from DNA that are safe for the body and don’t trigger immune responses. In aesthetic medicine, they are valued for their ability to repair tissues, activate fibroblasts, and boost collagen production, helping with skin regeneration.
Whose DNA is being used in Polynucleotide treatments?
This is a common question! The DNA comes from salmon. Interestingly, salmon DNA closely resembles human DNA in structure. Importantly, only small fragments of DNA are used, and they go through rigorous purification processes, leaving no physical residue. Even individuals allergic to fish can safely use these treatments, as studies show no allergic reactions. Additionally, the salmon are not harmed to extract the DNA.
What is the difference between Polynucleotides and skin booster injections?
Polynucleotides provide hydration, stimulate skin regeneration, activate fibroblasts, and enhance collagen production. Skin boosters, while excellent for hydration and skin plumping, don’t encourage long-term regeneration and are more temporary in their effects.
How is the Polynucleotide procedure performed?
Polynucleotides are injected into the skin through tiny, precise micro-injections. These minimally invasive procedures are carried out by highly trained professionals, ensuring both comfort and effective results.
Is the Polynucleotide treatment painful?
The treatment itself is generally not very painful. A numbing cream is applied beforehand, and fine needles are used to minimize discomfort. Some people might feel mild discomfort, depending on their sensitivity.
How long do the results of Polynucleotide treatments last?
Results typically last between 6 and 12 months after initial treatment, depending on factors such as the individual’s age and specific skin concerns being treated.
Can Polynucleotides be combined with other aesthetic procedures?
Yes, Polynucleotide treatments work well alongside most aesthetic procedures. Combining them can enhance overall results, offering a comprehensive approach to skin rejuvenation.
Polynucleotide treatment vs. Botox
Polynucleotide (PN) and Botox are popular injectable treatments with unique benefits. PN enhances skin elasticity, hydration, and texture, promoting natural rejuvenation with minimal side effects, making it ideal for sensitive skin. Often combined with dermal fillers or hyaluronic acid, it offers comprehensive revitalization. Botox effectively reduces dynamic wrinkles like crow’s feet, providing results for 3-6 months, though minor side effects like localized pain can occur. The choice depends on whether hydration or wrinkle reduction is the primary goal.
